By Dr Pranab Gyawali, Consultant Gastroenterologist
Many of my patients with Crohn’s disease or ulcerative colitis in Dubai feel anxious when they hear about “biologic treatments.” If you were in clinic with me in Dubai and we were about to start a biologic, this is exactly how I explain how these medicines work — and why they’ve changed the way we treat IBD. I hope you find it helpful.
What are biologics for Crohn’s and colitis?
Biologics are advanced medicines used for inflammatory bowel disease (IBD). They are not steroids or general immune suppressants — they target only the immune signals that cause gut inflammation.
Why does inflammation happen in IBD?
In Crohn’s and ulcerative colitis, the immune system mistakes the intestinal lining for infection and attacks it, causing ulcers, pain, bleeding, and fatigue. If this continues unchecked, it can damage the bowel — biologics help stop this early.
How do biologics actually work in Crohn’s and colitis?
If you were sitting with me in clinic, I’d explain it like this: your immune system is like an orchestra. In IBD, one section plays too loud — biologics act like the conductor, restoring balance.
- Infliximab and Hyrimoz block TNF.
- Entyvio blocks α4β7 integrin so excess immune cells can’t enter the gut wall.
- Skyrizi and Rinvoq target IL-23 and JAK pathways.
What improvements do patients notice?
As inflammation settles, patients usually notice fewer bowel motions, less bleeding, and improved energy. Over time, the bowel lining repairs — mucosal healing — and flare-ups become far less frequent.
Are biologics safe for Crohn’s and ulcerative colitis in Dubai?
Yes. Biologics such as Entyvio, Skyrizi, Hyrimoz, Rinvoq, and Infliximab are widely used in Dubai and internationally with excellent safety records. Patients are screened, vaccinated, and monitored with blood tests, faecal calprotectin, and sometimes endoscopy.
Where can patients access biologic treatment in Dubai?
Dr Pranab Gyawali is experienced with both originator and biosimilar biologics — including Infliximab, Entyvio, Hyrimoz, Skyrizi, and Rinvoq — following international IBD guidelines. Treatments are individualized and monitored closely for safety and response.
Recommended Guides for Biologics, Crohn’s and Colitis
1. Understanding IBD
- Next Generation Probiotics in IBD: SER-603 and Microbiome Therapy
- FMT and Infliximab in IBD: Could the Microbiome Help Biologics Work Better?
- Dual biological pathway blocking in Crohn’s and colitis
- Crohn’s Disease – Symptoms, Tests & Treatment in Dubai
- Ulcerative Colitis – Symptoms, Tests & Treatment in Dubai
- How Biologics Work in Crohn’s & Colitis
- Crohn’s & Colitis: Why You Shouldn’t Stay on Steroids
- Is Your Gut Really Healed? Understanding Deep Remission
- Ulcerative Colitis Progression in Dubai
- Rectal Bleeding
- SIBO in Crohn’s & Ulcerative Colitis
2. Choosing the Right Advanced Treatment
- Next generation stool test in IBD: Granzyme A explained
- New TL1A inhibitor (tulisokibart) – can response be predicted before treatment?
- CAR-T Therapy in Crohn’s Disease – What Patients Need to Know
- Predicting Biologic Treatment Success in Crohn’s & Ulcerative Colitis
- Stelara vs Skyrizi Crohn’s Study Explained
- Tremfya (Guselkumab) Explained
- Tremfya (Guselkumab) in Ulcerative Colitis: Does It Keep Patients Well Long Term?
- Rinvoq – How It Works for Crohn’s & UC
- Predicting Vedolizumab Response Early in IBD
- Vedolizumab in Crohn’s Disease: Why Timing May Change Results
- Icotrokinra: Oral IL-23 Therapy for Crohn’s and Ulcerative Colitis?
- Crohn’s Surgery vs Infliximab in Dubai
- Biologicals & Pregnancy
- 5-ASA – Why It Still Matters
3. Diet, Microbiome and Treatment Response
- Should you avoid dairy in Crohn’s and ulcerative colitis?
- Diet, inflammation monitoring and IBD flare risk
- How the Oxygen Trap May Be Driving Your IBD — And Why Diet Still Matters
- Diet, Microbiome & IBD
- What Leaky Gut Really Means in IBD
- Top Leaky Gut Supplements
- Stress & the Gut–Brain Axis in IBD
- Aloe Vera for Crohn’s & UC
- Black Cumin Seed Oil for IBD
- Vitamin D & Gut Health
- Supplements & Gut Health
- Gluten & IBD — Any Connection?
- Curcumin & Qing Dai in Ulcerative Colitis
4. Tests, Monitoring and Safety
- Flu Vaccines for IBD Patients on Biologics
- Iron Deficiency & Anaemia in IBD
- B12 & Folate Deficiency in IBD
- Colonoscopy
- Capsule Endoscopy
- Diagnostic Tests for Gastrointestinal Disorders
- Hydrogen & Methane Breath Test
- Gut Microbiome Test
- MRI Abdomen / MR Enterography
- CT Abdomen / CT Enterography
If you wish to discuss this further or would like to make an appointment, please use the booking form on this page. Expect a response within 12 business hours.