By Dr Pranab Gyawali, Consultant Gastroenterologist
Is Infliximab Safe During Pregnancy? A Dubai Gastroenterologist Explains
A Common and Important Question
I saw a patient recently who asked a very important question:
“Can I get pregnant while I’m on infliximab?”
“Is it safe to stay on biologics if I’m planning a baby?”
These are questions I get often in my IBD clinic—from women living with Crohn’s disease or ulcerative colitis who are thinking about pregnancy.
If you’ve asked the same, this article will help guide you through what the latest guidelines say, and how we approach it in real life.
Who I Am
I’m Dr. Pranab, a consultant Gastroenterologist trained and practiced in London, now based in Dubai.
I’ve looked after many women with IBD through pregnancy—including those on biologics like infliximab (Remicade)or adalimumab (Humira)—before, during, and after they give birth.
We now have excellent data and strong international guidance to help you make informed, confident decisions.
What the BSG 2025 Guidelines Say
The British Society of Gastroenterology (BSG) 2025 guidelines are very clear:
“Active disease during conception and pregnancy carries a higher risk than continuing effective maintenance therapy.”
Staying in remission is more important than stopping medication.
Biologics like infliximab can help keep your disease well controlled. If they’re working for you, continuing them may be the safest approach.
What the Research Says About Baby Outcomes
You’re not alone in worrying about the baby’s safety.
But large studies, like the PIANO registry, give us strong reassurance:
- No increase in birth defects
- No increase in infections in infants
- Normal developmental outcomes
Babies born to mothers on infliximab do just as well as those who weren’t exposed—especially when the mother is in remission during pregnancy.
What About Timing and Vaccines?
If infliximab is continued into the third trimester, small amounts can pass to the baby across the placenta.
This doesn’t usually cause harm, but it does mean that certain live vaccines, such as:
- BCG (for tuberculosis)
- Rotavirus
may need to be delayed until around 6 to 12 months of age.
Don’t worry—your paediatrician will guide you on the safest vaccination schedule.
All non-live vaccines can be given as normal.
My Advice to Women Planning Pregnancy
If you’re living with Crohn’s or colitis and thinking about starting a family:
- Talk to your gastroenterologist early
- Don’t stop or change treatment without advice
- Make remission the goal before conceiving
- And don’t be afraid of continuing medication if it’s keeping you well
Biologics like infliximab can be part of a safe, successful pregnancy.
Key Takeaways
- Infliximab is generally safe in pregnancy
- Being in remission is more important than stopping treatment
- Babies exposed to biologics do well in long-term studies
- Some live vaccines may need to be delayed
- Always individualize decisions with your own doctor
Need Help with Crohn’s, Colitis, or IBD Pregnancy Planning in Dubai?
I offer expert consultations for patients with Crohn’s disease, ulcerative colitis, and other complex gut conditions—including those planning for pregnancy.
Visit: www.GutHealthDubai.com
Book a consultation to get personalized, evidence-based advice.