By Dr Pranab Gyawali, Consultant Gastroenterologist
Over the last 25 years, I’ve treated thousands of patients with Crohn’s disease, ulcerative colitis (UC), and IBS.
And one question that keeps coming up—especially after my recent videos—is this:
“Do any supplements actually help heal leaky gut, especially in IBD?”
This post is Part 3 of my leaky gut series.
In Parts 1 & 2, we covered what leaky gut is, how it relates to Crohn’s and colitis, and how lifestyle and food choices can help support your gut lining.
But many of you wanted a deeper dive into the specific supplements I mentioned—especially the ones commonly promoted online.
So in this article, I break down the three most popular supplements people ask me about—and how I personally rate them based on the science.
1. L-Glutamine
What it does:
L-glutamine is the main fuel source for the cells lining your gut. It supports tight junction repair, reduces inflammation, and may help rebuild a damaged barrier.
Evidence in leaky gut/IBS:
- Strong support from animal and in vitro studies
- Shown to help in athletes, chemotherapy patients, and IBS
Rating: 8 /10
Evidence in Crohn’s/UC:
Mixed results. Some small studies show benefit in symptom reduction or healing post-surgery, but no major effects in active disease.
Rating: 5/10
Food sources:
Chicken, turkey, spinach, cabbage, eggs, bone broth
My take:
Worth considering in remission or IBS-type symptoms, but not a cure-all.
2. Zinc Carnosine (Polaprezinc)
What it does:
Zinc-carnosine is used widely in Japan to heal gastric ulcers. It helps stimulate mucin production, reduce inflammation, and promote mucosal healing.
Evidence in leaky gut/NSAID injury:
Good data from animal models and small clinical trials
Rating: 8 /10
Evidence in UC/Crohn’s:
One human study showed improved endoscopic healing in mild-to-moderate UC
Less evidence in Crohn’s
Rating: 6/10
Important:
This is not the same as regular zinc. Use the zinc-carnosine complex form. Can cause copper deficiency if taken in high doses.
My take:
Promising in mild UC or NSAID injury, but not well studied in Crohn’s.
3. Saccharomyces boulardii
What it does:
This probiotic yeast can help restore balance in the gut microbiome, reduce gut permeability, and protect the barrier during stress or antibiotic use.
Evidence in IBS/leaky gut:
Effective in traveler’s diarrhea, IBS-D, and antibiotic-associated diarrhea
Rating: 8/10
Evidence in IBD:
Some small studies suggest reduced Crohn’s relapse rates.
Less consistent benefit in UC
Avoid during active flares or immunosuppression
Rating: 5-6/10
My take:
Use with caution. May help in Crohn’s remission; less consistent in UC.
A Word of Caution
These supplements are not substitutes for medication.
If you have Crohn’s, UC, or IBS, always consult your IBD specialist or gastroenterologist before starting anything new—especially if you're on biologics, steroids, or immunosuppressants.
I share these insights because many of my patients have heard about these supplements online and want evidence-based answers.
I regularly see patients in Dubai with Crohn’s disease, ulcerative colitis, IBS, and gut-related autoimmune issues.
If you’re looking for personalized care, functional gut support, or help navigating gut healing in IBD—feel free to book a consultation.
For leaky gut, Crohn’s, UC, or IBS — real results come from a combination of personalised treatment, evidence-based diet, stress management, sleep, and targeted supplements when appropriate.
Explore more on gut health in Dubai
Frequently Asked Questions (FAQs)
What is the best supplement for leaky gut?
There’s no “one size fits all.” L-Glutamine, Zinc Carnosine, and Saccharomyces boulardii can help — but only if used correctly, with medical guidance.
Can I use supplements instead of medication for Crohn’s or UC?
No. Supplements may support gut healing, but they are not a replacement for your prescribed IBD treatment plan.
Where can I get gut health advice in Dubai?
If you live in Dubai and want trusted, personalised care for Crohn’s, UC, or IBS, I’d be happy to help you at my clinic.
Is Saccharomyces boulardii safe for Crohn’s or UC?
It can help prevent relapse in UC when stable — but it’s not recommended during active flares or when using immunosuppressants.
Let’s Keep Your Gut Strong — Together
If you’re exploring safe, evidence-based ways to support your gut barrier, you’re in the right place.
For all appointments and inquiries, please either WhatsApp +971 58 905 6211 or click here to request an appointment online.