By Dr Pranab Gyawali, Consultant Gastroenterologist
A groundbreaking test may be changing how we diagnose and treat inflammatory bowel disease (IBD). In this latest vlog, Dr. Pranab Gyawali, a senior Consultant Gastroenterologist in Dubai, introduces a revolutionary diagnostic tool: Multiplex Droplet Digital PCR. This new stool-based test can analyze gut microbiome imbalances and detect IBD—including Crohn’s disease and ulcerative colitis—with up to 90% accuracy.
Dr. Gyawali, who specializes in IBD management and microbiome health, explains how the future of personalized gut care is already here.
What Is Multiplex Droplet Digital PCR?
This advanced test uses stool samples to:
- Detect imbalances in the gut microbiome (known as dysbiosis)
-
Identify overgrowth of harmful bacteria like E. coli
- Measure reduction in beneficial bacteria such as Faecalibacterium
In a study involving over 5,000 stool samples, researchers found clear microbial differences between patients with IBD and those with other conditions like IBS. The test distinguished Crohn’s and colitis patients from non-IBD individuals with near 90% accuracy.
Explore IBD care and gut health services in Dubai
Why Is the Gut Microbiome Important in IBD?
IBD, including Crohn’s and ulcerative colitis, is often driven by inflammation caused by a disrupted gut microbiome. This test allows for:
- Earlier, more accurate diagnosis
-
Tailored treatment plans based on individual microbial patterns
- Better understanding of flare-up triggers and microbiome-supportive strategies
Dr. Gyawali emphasizes that even patients already on biologics, immunosuppressants, or steroids should consider protecting and supporting their microbiome.
Key Benefits of the Microbiome-Based IBD Test
- Non-invasive (stool sample based)
-
Highly accurate compared to traditional methods
-
Supports personalized care based on bacterial composition
- Enhances understanding of gut inflammation sources
FAQs by Patients
What is the new stool test for IBD diagnosis?
The test is called Multiplex Droplet Digital PCR. It analyzes gut microbiome patterns to detect Crohn’s disease and ulcerative colitis with high accuracy.
Can this test detect both Crohn’s and ulcerative colitis?
Yes. It identifies microbial imbalances linked to both Crohn’s and colitis and distinguishes IBD from IBS and other gut conditions.
Is microbiome testing available in Dubai?
Yes. Dr. Pranab Gyawali, a Consultant Gastroenterologist in Dubai, offers advanced microbiome testing as part of personalized IBD care.
Why should I get tested if I’m already on IBD medication?
Understanding your microbiome can help optimize dietary recommendations and protect gut health—even if you're already using steroids or biologics.
Recommended Guides:
FMT, Probiotics and Next-Generation Microbiome Therapies
- AI in Crohn’s and Ulcerative Colitis: Can Machine Learning Predict IBD Treatment Response?
- FMT and infliximab in IBD: could the microbiome help biologics work better?
- Fecal microbiota transplant for Crohn’s disease and ulcerative colitis
- Probiotics for Crohn’s and ulcerative colitis: what actually works?
- Probiotics in ulcerative colitis: what does the MB310 trial mean?
- Engineered probiotic for ulcerative colitis 2026
- Probiotics for ulcerative colitis: what actually works?
Gut Microbiome, Diet and Treatment Response
- Diet and microbiome in IBD: how the right bacteria calm gut inflammation
- Gut microbiome in Crohn’s disease and ulcerative colitis
- How the Oxygen Trap may be driving your IBD, and why diet still matters
- IBD flare risk, diet and calprotectin
- IBD breakthrough: how gut bacteria unlock natural anti-inflammatories
- Gut microbiome test in Dubai
Crohn’s, Colitis and Biologic Treatment Strategy
- Learn about Biologicals used in UC and Crohn’s in Dubai
- Crohn’s disease specialist care in Dubai
- Ulcerative colitis specialist care in Dubai
- How biologics work in Crohn’s and colitis
- How we choose the right biologic for Crohn’s and UC in Dubai
- New omics research: predicting response to biologics in Crohn’s and ulcerative colitis
Investigations and Procedures
- Colonoscopy for Crohn’s and ulcerative colitis monitoring
- Capsule endoscopy for small bowel Crohn’s disease
- MRI abdomen and MR enterography
- CT abdomen and CT enterography
- Hydrogen and methane breath test for SIBO
If you wish to discuss this further or would like to make an appointment, please use the booking form on this page.