By Dr Pranab Gyawali, Consultant Gastroenterologist
Video Discussion
A newly published preclinical study describes a next generation engineered probiotic for ulcerative colitis. This is not a biologic. It is a modified strain of E coli Nissle 1917 designed to survive in an inflamed colon.
Why Is This Different?
The engineered strain is designed to utilise tetrathionate, a chemical by product of intestinal inflammation, as a fuel source. Instead of struggling in inflammatory conditions, it is designed to grow within them.
What Did The Study Show?
Results come from animal models. The engineered strain showed improved colonisation, reduced inflammatory severity and improved survival compared with the unmodified strain. In porcine models, treated animals demonstrated improved mucosal integrity and lower mortality.
These findings are promising but remain preclinical. Human safety trials are planned.
Study Reference
Horgan K et al. Development of a Next Generation Engineered Live Microbiome Biotherapeutic, E coli Nissle 1917 TTR, for Ulcerative Colitis. Inflammatory Bowel Diseases. 2026;32(Supplement_1).
How Does This Fit With Current Treatment?
Current ulcerative colitis therapy focuses on immune pathway suppression through anti TNF, IL 23 inhibitors and JAK inhibitors. Microbiome derived therapies approach disease from a different angle by modifying the intestinal environment rather than directly suppressing immune signalling.
It is unlikely to replace biologics. However, it may influence future combination strategies and flare prevention.
Learn More About The Microbiome
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Gut Microbiome, Leaky Gut & Overlooked Issues
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Related Gastroenterology Topics
Digestive Conditions
- Gut Microbiome Test
- Irritable Bowel Syndrome (IBS)
- Crohn’s Disease
- Acid Reflux Treatment
- Gastritis
- H- Pylori Treatment
- Abdominal Pain
- Bloating
- Constipation
- Fatty Liver
- Rectal Bleeding
- Functional Dyspepsia
- Eosinophilic Esophagitis
- Food Intolerances
- Hemorrhoids
Diagnostic Tests & Procedures
- Hydrogen & Methane Breath Test (SIBO)
- Capsule Endoscopy
- Gastroscopy
- Colonoscopy
- CT Abdomen / CT Enterography
- MRI Abdomen / MR Enterography
- Urea Breath Test
- Fecal H. pylori Antigen
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